Immunoglobulin M: Pentameric Fc Fragments Released by Trypsin at Higher Temperatures
نویسندگان
چکیده
منابع مشابه
Signal transduction by immunoglobulin Fc receptors.
Receptors for the Fc portion of immunoglobulin molecules (FcR) present on leukocyte cell membranes mediate a large number of cellular responses that are very important in host defense. Cross-linking of FcR by immune complexes leads to functions such as phagocytosis, cell cytotoxicity, production and secretion of inflammatory mediators, and modulation of the immune response. Molecular characteri...
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Removal of the fucose residue from the oligosaccharides attached to Asn297 of human immunoglobulin G1 (IgG1) results in a significant enhancement of antibody-dependent cellular cytotoxicity (ADCC) via improved IgG1 binding to Fcgamma receptor IIIa. To provide structural insight into the mechanisms of affinity enhancement, we determined the crystal structure of the nonfucosylated Fc fragment and...
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Four types of Fc fragments of different sizes were isolated by papain treatment of rabbit immunoglobulin G under various conditions and by subsequent chromatographic procedures. 1. Brief digestion at neutral pH without reduction produced a molecule in which the Fab and Fc fragments were still linked by a pair of labile disulphide bridges, and the Fc fragment released by cleaving these bonds, ca...
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This paper presents results from a research initiative aimed at investigating high temperature creep deformation mechanisms in Ni-base superalloys through a combination of creep experiments, TEM deformation mechanism characterization, and state of the art modeling techniques. The effect of microstructure on dictating creep rate controlling deformation mechanisms was revealed for specimens with ...
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In spite of obvious possible sources of disturbance, the "velocity of killing" of organisms at supranormal temperatures, properly determined, tends to adhere to the Arrhenius equation for relation to temperature. Over certain ranges of temperature the relationship between log velocity of killing and 1/T degrees abs. is linear. Interpreted as due to the thermal denaturing of protein, it is possi...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1970
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.65.2.318